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Cellular Antenna Making Waves

Updated: Oct 12

Did you know you have your own built-in WIFI?


An organism’s perception of its natural environment is dependent on sensory function. As sensors of our environment, cilia are involved in fundamental biological processes such as hearing, olfaction, and photoreception.


The cilium, plural cilia (from Latin 'eyelash') acts as our cellular antennae providing chemosensation, thermosensation, and mechanosensation of the extracellular environment. In effect, the cilia act as nanomachines composed of perhaps over 600 proteins.


All life exists within a sea of frequency, vibration, and rhythm is fundamental to all of life.


“If you want to find the secrets of the universe, think in terms of energy, frequency, and vibration.” ― Nikola Tesla


These cilia are short microscopic hairlike vibrating structures found in large numbers on the surface of certain cells causing currents in the surrounding fluid.


Cilia can be either motile or nonmotile. Motile cilia are used to move the cell, for example in the respiratory epithelium. Nonmotile or primary cilia are used to sense not only external cues including signals from the environment of the organism such as light, odor, and tastants but also cues internal to the organism such as fluid flow, Hedgehog (Hh), and Wnt signals, growth factors, and others.


As previously mentioned, cilia act as a cellular ‘antenna’ that receives diverse signals from the extracellular environment, including light, low molecular weight chemicals, proteins, and mechanical stimuli. Their importance is further highlighted by the studies of a group of diseases, known as ciliopathies, which include cystic kidney disease, neurodevelopmental abnormalities, blindness, obesity, and perhaps even psychiatric disorders.


The Terahertz Frequency DICTATES THE FREQUENCY OF LIFE.


In fact, it’s been called “THE WAVE OF LIFE”, “LIGHT OF LIFE”, “DIVINE FREQUENCY”, and “GOD’S WAVEBAND.”


Essentially the terahertz frequency is photon light. The body itself is a heat source that absorbs or emits terahertz waves (light). When high-frequency terahertz waves are used on the body, the cells receive a large number of negative ions that cancel out the excessive accumulation of positive ions in the cellular environment of the body, thereby “recharging” the cells and activating them.


Our cellular antenna (cilia) would be directly involved in picking up these light waves from the terahertz frequency!


Light Moves Cilia To A Complex Beat


Cilia, which cover the free surface of some cells almost like blades of grass in a lawn, beat in unison at a rate of as much as 100 beats per second. The surface of an epithelial cell contains from 50 to 200 cilia. Much like rowing a boat, a ciliary beat has a power stroke that propels either the cell through a liquid or mucus over a cell that is fixed in place.


Cilia are particularly important in vision because they work as light sensors and defects in their structure can lead to retinal degeneration and loss of vision.


This sensory and signaling role puts cilia in a central role in maintaining the local cellular environment and may be why ciliary defects cause such a wide range of human diseases. The importance of cilium in signaling and cell biology is highlighted by the wide range of defects and disorders, collectively known as ciliopathies.


Ciliary defects can lead to a number of human diseases. Defects in cilia cells are linked to obesity and are often pronounced in type 2 diabetes. Several studies already showed impaired glucose tolerance and reduction in insulin secretion in the ciliopathy models. Moreover, the number and length of cilia were decreased in the type 2 diabetes models. Insulin-secreting beta cells and glucagon-secreting alpha cells are highly ciliated.


Reduction of cilia function can also result from infection. Research into biofilms has shown that bacteria can alter cilia. A biofilm is a community of bacteria of either the same or multiple species of bacteria. The cluster of cells secretes different factors which form an extracellular matrix.


Cilia in the respiratory system are known to move mucus and pathogens out of the airways. The bronchus in the lungs is lined with hair-like projections called cilia that move microbes and debris up and out of the airways. It has been found that patients with biofilm-positive infections have impaired cilia function. The impairment may present as decreased motion or a reduction in the number of cilia. Impaired airway clearance prevents the elimination of dust particles, pathogens, etc., trapped in mucus from the airways.


Autophagy is a catabolic process that degrades organelles and long-lived proteins and maintains cellular homeostasis by regulating the cellular energy balance and facilitating organelle quality control. The autophagic machinery is highly sensitive to intracellular and extracellular stress cues. The adaptive autophagy mechanism is a part of an integrated series of responses by which cells respond to stress stimuli. Recent studies have elucidated a close reciprocal relationship between primary cilia and the autophagic machinery. In addition, primary cilia mediate mitochondrial stress responses.


Impact of Defective Cilia


Defective and dysfunctional functioning in motile and non-motile cilia result in a large number of symptoms and disorders which have a significant impact on those affected.


Defective and dysfunctional functioning in motile and non-motile cilia affects multiple systems, causing blindness, deafness, chronic respiratory infections, kidney disease, heart disease, infertility, obesity, and diabetes. These symptoms have a significant impact on those affected; some are devastating, and most are life-threatening.


Patients with ciliopathies affecting the inner ear are often deaf and/or exhibit balance difficulties.


Patients with an affected olfactory epithelium often show a complete loss of smell (anosmia), and patients with retinal ciliopathies often become blind (retinal degeneration).


In summary, cilia remove inhaled pathogens from the respiratory tract, carry cerebrospinal fluid across brain cavities, transport eggs from the ovary to the uterus, drain mucus from the middle ear to the nasal cavity, and much more!


These tiny, extracellular organelles exert precise microfluidic control over life-sustaining liquids in the body. They are small, antenna-like organelles that detect and transduce chemical and mechanical cues in the extracellular environment, regulating cell behavior and, in turn, tissue development and homeostasis.


They transduce light and mechanical and chemical cues, mediate signaling pathways, and regulate cell cycle, cell differentiation, cell-cell communication, and autophagy. The multiplicity and importance of these functions render primary cilia vital for organismal development and homeostasis.


Sources:


https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/cilium


https://en.wikipedia.org/wiki/Cilium


https://www.nature.com/articles/s41419-019-2184-y


https://www.ciliopathyalliance.org/cilia


https://reactome.org/PathwayBrowser/#/R-HSA-5617833


https://pubmed.ncbi.nlm.nih.gov/25805137/


https://source.wustl.edu/2019/03/making-waves-researchers-shed-light-on-how-cilia-work/


https://www.bcm.edu/news/zooming-into-cilia-sheds-light-on-blinding-diseases


https://www.mdpi.com/2073-4409/4/3/500/pdf-vor


https://www.frontiersin.org/articles/10.3389/fcell.2021.661350/full


https://medicalxpress.com/news/2013-05-ventricular-volume-ciliary-frequency.html


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